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Science 3 March 1972:
Vol. 175. no. 4025, pp. 1022 - 1023
DOI: 10.1126/science.175.4025.1022
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Articles

Dgr9-Tetrahydrocannabinol and Ethyl Alcohol: Evidence for Cross-Tolerance in the Rat

L. Michael Newman 1, Michael P. Lutz 1, Michael H. Gould 1, and Edward F. Domino 1

1 Department of Pharmacology, University of Michigan, Ann Arbor

Rats trained in a one-way avoidance situlation were made tolerant to the depressant effects of Dgr9-tetrahydrocannabinol. Ethyl alcohol (3.2 grams per kilogram, intraperitoneally) did not greatly affect rats that were tolerant to dgr9tetrahydrocannabinol but depressed the behavior of nontolerant rats. Rats made tolerant to ethyl alcohol were less affected by Dgr9-tetrahydrocannabinol.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
ARE ANANDAMIDE AND CANNABINOID RECEPTORS INVOLVED IN ETHANOL TOLERANCE? A REVIEW OF THE EVIDENCE.
B. L. Hungund and B. S. Basavarajappa (2000)
Alcohol Alcohol. 35, 126-133
   Abstract »    Full Text »    PDF »
Lack of Tolerance to Dgr9-Tetrahydrocannabinol in Chimpanzees.
D. P. Ferraro and D. M. Grilly (1973)
Science 179, 490-492
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)