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Science 3 March 1972:
Vol. 175. no. 4025, pp. 1012 - 1014
DOI: 10.1126/science.175.4025.1012
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Articles

Mast Cells from Human Respiratory Tissue and Their in vitro Reactivity

Roy Patterson 1, Louis R. Head 1, Irena M. Suszko 1, and C. Raymond Zeiss Jr. 1

1 Section of Allergy-Immunology, Department of Medicine; Department of Surgery, Northwestern University Medical Center, Chicago, Illinois 60611

Human respiratory mast cells, which were obtained coincidentally with diagnostic bronchial brush biopsy, were maintained under conditions for short-term tissue culture. Most mast cells were viable and degranulated on exposure to antibody to immunoglobulin E or to the mast cell degranulating agent compound 48-80. The degranulation of human mast cells is characteristically an intracellular process with no extracellular extrusion of granules.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)