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Science 25 February 1972:
Vol. 175. no. 4024, pp. 911 - 912
DOI: 10.1126/science.175.4024.911
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Articles

Dgr9-Tetrahydrocannabinol: Aversive Effects in Rat at High Doses

Timothy F. Elsmore 1 and Gordon V. Fletcher 1

1 Department of Experimental Psychology, Walter Reed Army Institute of Research, Washington, D.C.

Water-deprived rats were administered a single dose of Dgr9-tetrahydrocannabinol either orally or intraperitoneally immediately after their first taste of a saccharine solution. In tests beginning 47 hours after drug administration, a dose-related reversal of rats' normal preference for saccharine was found. The data suggest that the drug produces aversive effects at doses of 1 to 32 milligrams per kilogram.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cannabinoid Addiction: Behavioral Models and Neural Correlates.
R. Maldonado and F. Rodriguez de Fonseca (2002)
J. Neurosci. 22, 3326-3331
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Science. ISSN 0036-8075 (print), 1095-9203 (online)