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Science 25 February 1972:
Vol. 175. no. 4024, pp. 909 - 911
DOI: 10.1126/science.175.4024.909
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Articles

Synthetic Strands of Cardiac Muscle: Growth and Physiological Implication

Melvyn Lieberman 1, Anne E. Roggeveen 1, Joyce E. Purdy 1, and Edward A. Johnson 1

1 Department of Physiology and Pharmacology, Duke University Medical Center, Durham, North Carolina 27710

Cardiac muscle cells obtained fronm disaggregated embryonic chick hearts were cultured on difjerentially treated oriented substrata. Subsequent cell reaggregation, growth, and attachmwent produced linearly organized strands of cardiac muscle with dimensions suitable for electrophysiological analysis. Along the strand, areas that contained few muscle cells demonstrated reduced conduction velocity and were subject to propagation failure.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)