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Science 25 February 1972:
Vol. 175. no. 4024, pp. 903 - 905
DOI: 10.1126/science.175.4024.903
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Articles

Isozymes of Phenylalanine Hydroxylase

John A. Barranger 1, Paul J. Geiger 1, A. Huzino 1, and Samuel P. Bessman 1

1 Department of Pharmacology, University of Southern California School of Medicine, Los Angeles 90033

Three isozymes of phenylalanine hydroxylase exist in adult rat liver. They are chromatographically unique. Partial chracterization suggests that they are similar in chemical properties and differ only in charge. Estimation of the Stokes radii indicates that the isozymes have similar molecular weights of about 200,000. Two isozymes exist in human fetal liver. Alterations of the relative amounts of these isozymes may control the phenotype of the disease phenylketonuria.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Gene transfer and expression of human phenylalanine hydroxylase.
F. Ledley, H. Grenett, A. DiLella, S. Kwok, and S. Woo (1985)
Science 228, 77-79
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Science. ISSN 0036-8075 (print), 1095-9203 (online)