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Science 18 February 1972:
Vol. 175. no. 4023, pp. 757 - 758
DOI: 10.1126/science.175.4023.757
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Articles

Cyclic Nucleotide Phosphodiesterase: High Activity in a Mammalian Photoreceptor

R. G. Pannbacker 1, D. E. Fleischman 1, and D. W. Reed 1

1 Charles F. Kettering Research Laboratory, Yellow Springs, Ohio 45387

Purified outer segments of bovine rods exhibit phosphodiesterase activity against adenosine and guanosine cyclic 3',5'-monophosphates (cyclic AMP and cyclic GMP). The enzyme hydrolyzed cyclic GMP more rapidly than cyclic AMP at low substrate concentrations. The presence of high phosphodiesterase activity in this highly specialized organelle suggests that this enzyme may function in control of cyclic nucleotide concentration during visual excitation or adaptation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The chemistry of vision.
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Control of Guanylate Cyclase Activity in the Rod Outer Segment.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)