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Science 11 February 1972:
Vol. 175. no. 4022, pp. 654 - 656
DOI: 10.1126/science.175.4022.654
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Articles

Growth Retardation in Offspring of Female Rats Treated with Morphine Prior to Conception

Gladys Friedler 1 and Joseph Cochin 2

1 Department of Pharmacology, Harvard Medical School, and Department of Anesthesia, Boston Hospital for Women, Boston, Massachusetts 02115
2 Department of Pharmacology, Boston University School of Medicine, Boston, Massachusetts 02118

Treatment of female rats with morphine sulfate for 5frac12 or 10 days, prior to drug withdrawal for 5 days and subsequent mating, results in retarded growth of offspring. The effect is not present at birth but appears at 3 to 4 weeks of age. It occurs even though offspring are not exposed to morphine in utero or postnatally. It is not eliminated by cross-fostering and is apparently of prenatal origin


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Early Growth Patterns of Methadone-Addicted Infants.
I. J. Chasnoff, R. Hatcher, and W. J. Burns (1980)
Arch Pediatr Adolesc Med 134, 1049-1051
   Abstract »    PDF »
Early Development of Infants of Heroin-Addicted Mothers.
G. S. Wilson, M. M. Desmond, and W. M. Verniaud (1973)
Arch Pediatr Adolesc Med 126, 457-462
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)