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Science 11 February 1972:
Vol. 175. no. 4022, pp. 642 - 644
DOI: 10.1126/science.175.4022.642
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Articles

Cytochalasin B: Effects on Microfilaments and Movement of Melanin Granules within Melanocytes

Joseph McGuire 1 and Gisela Moellmann 1

1 Clinical Research Training Program and Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06510

The intracellular translocation of melanin granules within both epidermal and dermal melanocytes of Rana pipiens is influenced by cytochalasin B. Cytochalasin B prevents dispersion of pigment granules by melanocytestimulating hormone (MSH) and causes centripetal movement of pigment granules that have been dispersed by MSH. Microfilaments are abundant in the dendritic processes of epidermal melanocytes in which pigment granules have been dispersed by MSH. Microfilaments are dramatically reduced in number in the processes of melanocytes that have been lightened by cytochalasin B. These observations suggest that microfilaments mediate dispersion of pigment granules.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Regulation of Organelle Movement in Melanophores by Protein Kinase A (PKA), Protein Kinase C (PKC), and Protein Phosphatase 2A (PP2A).
A. R. Reilein, I. S. Tint, N. I. Peunova, G. N. Enikolopov, and V. I. Gelfand (1998)
J. Cell Biol. 142, 803-813
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Vasopressin: Possible Role of Microtubules and Microfilaments in Its Action.
A. Taylor, M. Mamelak, E. Reaven, and R. Maffly (1973)
Science 181, 347-350
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Cytochalasin B Prevents Specific Sorting of Reaggregating Embryonic Cells.
D. E. Maslow and E. Mayhew (1972)
Science 177, 281-282
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Science. ISSN 0036-8075 (print), 1095-9203 (online)