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Science 11 February 1972:
Vol. 175. no. 4022, pp. 637 - 638
DOI: 10.1126/science.175.4022.637
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Articles

Ovulation in Hamster: Induction by beta Subunit of Ovine Interstitial Cell Stimulating Hormone

W. H. Yang 1, M. R. Sairam 1, Harold Papkoff 1, and Choh Hao Li 1

1 Hormone Research Laboratory, University of California, San Francisco 94122

As little as 5 micrograms of interstitial cell stimulating hormone (ICSH) or 20 micrograms of ICSH-beta is effective for the induction of ovulation in 100 percent of hamsters treated at 0500 hours on day 4 after lordosis, whereas as much as 800 micrograms of ICSH-agr is ineffective. Both ICSH and ICSH-beta are also effective for induction of ovulation in hypophysectomized animals. Thus, the ovulation-inducing activity of the ICSH molecule resides in its beta subunit.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)