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Science 4 February 1972:
Vol. 175. no. 4021, pp. 530 - 533
DOI: 10.1126/science.175.4021.530
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Articles

Microsomal Lipid Peroxidation: Morphological Characterization

A. U. Arstila 1, Mary A. Smith 1, and B. F. Trump 1

1 Department of Pathology, University of Maryland School of Medicine, Baltimore 21201

Lipid peroxidation of liver and kidney microsomes induces a highly characteristic sequence of morphological changes typified by detachment of ribosomes and formation of large aggregates of vesicles bound together by dense amorphous material and myelin figure-like debris. The trilaminar structure of the membrane is, however, retained even after complete peroxidation, though its spacing may be increased. The aggregates resemble lysosomal lipofuscin pigment as well as the membranous aggregates of endoplasmic reticulum seen in the liver after carbon tetrachloride poisoning.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Ultrastructural Localization of Light-Induced Lipid Peroxides in the Rat Retina.
P. Kayatz, K. Heimann, and U. Schraermeyer (1999)
Invest. Ophthalmol. Vis. Sci. 40, 2314-2321
   Abstract »    Full Text »    PDF »
Response of Hepatic Endoplasmic Reticulum to Drugs and Chemicals.
F. G. Zaki (1976)
Toxicol Pathol 4, 11-20
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Science. ISSN 0036-8075 (print), 1095-9203 (online)