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Science 4 February 1972:
Vol. 175. no. 4021, pp. 529 - 530
DOI: 10.1126/science.175.4021.529
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Articles

Crystalline Cholera Toxin and Toxoid

Richard A. Finkelstein 1 and Joseph J. Lospalluto 1

1 Departments of Microbiology and Biochemistry, University of Texas Southwestern Medical School, Dallas 75235

The exo-enterotoxin of Vibrio cholerae has been obtained in crystalline form. A solution of the crystalline protein was equal in potency to the parent pure toxin in both choleragenicity and skin reactivity. Crystals of the natural toxoid, choleragenoid, resemble those of the toxin in appearance. A solution of crystalline choleragenoid was equivalent to the parent preparation in the flocculation test.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)