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Science 28 January 1972:
Vol. 175. no. 4020, pp. 454 - 456
DOI: 10.1126/science.175.4020.454
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Articles

Operant Behavior Changes Norepinephrine Metabolism in Rat Brain

Alfred J. Lewy 1 and Lewis S. Seiden 1

1 Departments of Pharmacology and Psychiatry, University of Chicago, Chicago, Illinois 60637

Rats performing a lever-pressing response for water reward in an operant situation, when compared with control groups, showed an increase in brain norepinephrine metabolism. One control group included rats which were handled and deprived of water in the same way as the experimental group but were not trained to perform the operant task. We conclude that performance in an operant situation affects norepinephrine metabolism.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Peter B. Dews and Pharmacological Studies on Behavior.
J. E. Barrett and J. Bergman (2008)
J. Pharmacol. Exp. Ther. 326, 683-690
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Science. ISSN 0036-8075 (print), 1095-9203 (online)