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Science 21 January 1972:
Vol. 175. no. 4019, pp. 331 - 333
DOI: 10.1126/science.175.4019.331
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Articles

Gamma-Aminobutyric Acid Antagonism and Presynaptic Inhibition in the Frog Spinal Cord

Robert A. Davidoff 1

1 Neurology Service, Veterans Administration Hospital, and Department of Neurology, University of Miami School of Medicine, Miami, Florida 33152

The convulsant alkaloid bicuculline blocked presynaptic inhibition, dorsal root potentials, primary afferent depolarization, and depolarizing effects of gamma-aminobutyric acid on dorsal root terminals of the amphibian spinal cord, but did not block effects of other putative amino acid transmitters. These actions of bicuculline suggest that gamma-aminobutyric acid may be the transmitter involved in spinal presynaptic inhibition.


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