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Science 21 January 1972:
Vol. 175. no. 4019, p. 326
DOI: 10.1126/science.175.4019.326
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Articles

Sexual Stage of Histoplasma capsulatum

K. J. Kwon-Chung 1

1 Laboratory of Microbiology, National Institutes of Health, Bethesda, Maryland 20014

Twelve primary subcultures of Histoplasma capsulatum, paired in all possible combinations on agar containing yeast extract and Alphacel, produced fertile cleistothecia, resembling those of Ajellomyces dermatitidis (Blastomyces dermatitidis).


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Temperature-induced switch to the pathogenic yeast form of Histoplasma capsulatum requires Ryp1, a conserved transcriptional regulator.
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