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Science 14 January 1972:
Vol. 175. no. 4018, pp. 202 - 203
DOI: 10.1126/science.175.4018.202
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Articles

Morphological Transformation in vitro of Human Fibroblasts by Epstein-Barr Virus: Preliminary Observations

M. Probert 1 and M. A. Epstein 1

1 Department of Pathology, University of Bristol Medical School, Bristol BS8 1TD, England

Human embryo fibroblasts have undergone morphological transformation in vitro after infection by Epstein-Barr virus. The fibroblasts were maintained in suspension during exposure to the virus, and further treatment with inactivated Sendai virus increased the transformation rate. The transformed cells were large and polygonal and grew in discrete, heaped up, foci.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)