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Science 14 January 1972:
Vol. 175. no. 4018, pp. 194 - 196
DOI: 10.1126/science.175.4018.194
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Articles

Antibody-Dependent Lymphoid Cell-Mediated Cytotoxicity: No Requirement for Thymus-Derived Lymphocytes

John A. Van Boxel 1, John D. Stobo 1, William E. Paul 1, and Ira Green 1

1 Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014

The capacity of lymphoid cells from nonsensitized mice to lyse antibody-coated target erythrocytes in vitro does not require the presence of thymus-derived or thymus-dependent lymphocytes. Thus, spleen cells from thymus-deprived mice and spleen cell populations from which thymus-dependent lymphocytes had been removed were fully competent to mediate destruction of antibody-coated target cells. However, prior treatment of spleen cell populations with antibody to kgr chains diminished this function, suggesting a role for bone marrow-derived lymphocytes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Specific Suppression of Immune Responses.
D. A. Rowley, F. W. Fitch, F. P. Stuart, H. Kohler, and H. Cosenza (1973)
Science 181, 1133-1141
   Abstract »    PDF »
Microtubule Function in Immune and Nonimmune Lymphocyte-Mediated Cytotoxicity.
T. B. Strom, M. R. Garovoy, C. B. Carpenter, and J. P. Merrill (1973)
Science 181, 171-173
   Abstract »    PDF »


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