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Science 14 January 1972:
Vol. 175. no. 4018, pp. 187 - 189
DOI: 10.1126/science.175.4018.187
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Articles

Initiation of Protein Synthesis at an Unusual Position in an Immunoglobulin Gene?

O. Smithies 1 and M. D. Poulik 2

1 Laboratory of Genetics, University of Wisconsin, Madison 53706
2 Research Institute of West Beaumont Hospital, Royal Oak, Michigan 48072

The amino acid sequence of urinary beta2-microglobulin has been partially determined and found to be related to the constant region of IgG immunoglobulin heavy chain. beta2-Microglobulin is present in normal individuals. Its gene may have evolved from an immunoglobulin gene by the use of an unusually located start signal for initiating synthesis of the polypeptide.


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