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Science 14 January 1972:
Vol. 175. no. 4018, pp. 176 - 179
DOI: 10.1126/science.175.4018.176
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Articles

Diurnal Rhythm in Endoplasmic Reticulum of Rat Liver: Electron Microscopic Study

A. Chedid 1 and V. Nair 1

1 Laboratory of Neuropharmacology and Department of Pathology, Michael Reese Hospital, and Department of Pharmacology, Chicago Medical School, Chicago, Illinois 60612

Electron microscopy of rat hepatocytes revealed a diurnal variation in the relative amounts of endoplasmic reticulum structures and regional differences in their distribution within the hepatic lobule. The diurnal changes in smooth and rough endoplasmic reticulum structures were compared with the diurnal changes in the hepatic microsomal enzyme hexobarbital oxidase. In the control group, at the time when enzyme activity was maximum, the amount of smooth endoplasmic reticulum was also maximum and vice versa. When the enzyme rhythm was abolished, as in blinded rats, the diurnal rhythm in the endoplasmic reticulum was also abolished.


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