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Science 24 December 1971:
Vol. 174. no. 4016, pp. 1344 - 1346
DOI: 10.1126/science.174.4016.1344
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Articles

Hypertension of Renal Origin: Evidence for Two Different Mechanisms

Hans R. Brunner 1, J. Dianne Kirshman 1, Jean E. Sealey 1, and John H. Laragh 1

1 Department of Medicine, Columbia University, New York 10032

Antibody to angiotensin 11, or a specific peptide competitive inhibitor of angiolensin II, was used to investigate the role of the renin-angiotensin system in two types of renal hypertension in rats. The data indicate that angiotensin II is in fact critically involved in the pathogenesis of the form of renal hypertension in which one renal artery is clamped and the contralateral kidney is left in place, but that it probably plays no significant role in the maintenance of experimental renal hypertension in which the opposite kidney has been removed.


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