Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 24 December 1971:
Vol. 174. no. 4016, pp. 1336 - 1339
DOI: 10.1126/science.174.4016.1336
Prev | Table of Contents | Next

Articles

Carbonic Anhydrase Interaction with DDT, DDE, and Dieldrin

Y. Pocker 1, W. M. Beug 1, and V. R. Ainardi 1

1 Department of Chemistry, University of Washington, Seattle 98105

The active site of various carbonic anhydrases is not blocked by DDT. DDE, or dieldrin. Impairment of catalytic efficiency can only be documented in opalescent test solutions in which the insecticides are present in excess of their solubility limit. These slowly forming precipitates occlude enzyme from solution and furnish a physical explanation of the supposed inhibition. The amounts occluded depend, among other things, on the conformational and topographical characteristics of the particular carbonic anhydrase molecules.

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)