Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 17 December 1971:
Vol. 174. no. 4015, pp. 1240 - 1242
DOI: 10.1126/science.174.4015.1240
Prev | Table of Contents | Next

Articles

Suppression of Urethan-Induced Lung Adenomas in Mice Treated with Trehalose-6,6-Dimycolate (Cord Factor) and Living Bacillus Calmette Guérin

A. Bekierkunst 1, I. S. Levij 1, E. Yarkoni 1, E. Vilkas 2, and E. Lederer 2

1 Departments of Medical Bacteriology and Pathology, Hebrew University-Hadassah Medical School, Jerusalem, Israel
2 Institut de Chimie des Substances Naturelles, Gif-sur-Yvette, France

Trehalose-6,6-dimycolate (cord factor), a glycolipid from mycobacteria, suppressed the development of urethan-induced tumors in the lungs of mice to a similar degree as living Mycobacterium bovis (strain BCG) bacilli. The inhibition was apparently due to the host cellular reaction caused locally by cord factor.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Direct molecular mass determination of trehalose monomycolate from 11 species of mycobacteria by MALDI-TOF mass spectrometry.
Y. Fujita, T. Naka, T. Doi, and I. Yano (2005)
Microbiology 151, 1443-1452
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)