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Science 17 December 1971:
Vol. 174. no. 4015, pp. 1236 - 1237
DOI: 10.1126/science.174.4015.1236
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Articles

Snake Neurotoxins: Effect of Disulfide Reduction on Interaction with Electroplax

Eva Bartels 1 and Terrone L. Rosenberry 1

1 Department of Neurology, College of Physicians and Surgeons, Columbia University, New York 10032

Reduction of disulfide bonds of cobra neurotoxin by dithiothreitol results in decreased activity on the electroplax preparation. Activity is restored completely after reoxidation by 3,3'-dithiobis[6-nitrobenzoic acid]. Reduction of the disulfide bonds in the vicinity of the receptor does not decrease the effect of cobrotoxin.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)