Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 10 December 1971:
Vol. 174. no. 4014, pp. 1137 - 1139
DOI: 10.1126/science.174.4014.1137
Prev | Table of Contents | Next

Articles

Autoimmune Murine Thyroiditis Relation to Histocompatibility (H-2) Type

Adran O. Vladutiu 1 and Noel R. Rose 1

1 Center for Immunology and Department of Microbiology, State University of New York at Buffalo, Buffalo 14214

Immunization of 33 inbred strains of mice with thyroid extract emulsified in complete Freund's adjuvant showed differences in both thyroid autoantibody response and autoimmune thyroid damage, related to the histocompatibility (H-2) type of the strain. Congenic mice of the same H-2 type exhibited the same pattern of antibody response and thyroiditis, regardless of the strain's genetic background, thus showing a close relation between histocompatibility determinants and autoimmunity.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Immunization with thyroglobulin induces Graves'-like disease in mice.
T. Endo and T. Kobayashi (2009)
J. Endocrinol. 202, 217-222
   Abstract »    Full Text »    PDF »
Regenerative Potentials of the Murine Thyroid in Experimental Autoimmune Thyroiditis: Role of CD24.
C. Y. Chen, H. Kimura, M. A. Landek-Salgado, J. Hagedorn, M. Kimura, K. Suzuki, W. Westra, N. R. Rose, and P. Caturegli (2009)
Endocrinology 150, 492-499
   Abstract »    Full Text »    PDF »
Molecular amino acid signatures in the MHC class II peptide-binding pocket predispose to autoimmune thyroiditis in humans and in mice.
F. Menconi, M. C. Monti, D. A. Greenberg, T. Oashi, R. Osman, T. F. Davies, Y. Ban, E. M. Jacobson, E. S. Concepcion, C. W. Li, et al. (2008)
PNAS 105, 14034-14039
   Abstract »    Full Text »    PDF »
'Linkage Analysis of Thyroid Antibody Production: Evidence for Shared Susceptibility to Clinical Autoimmune Thyroid Disease.
Y. Ban, D. A. Greenberg, T. F. Davies, E. Jacobson, E. Concepcion, and Y. Tomer (2008)
J. Clin. Endocrinol. Metab. 93, 3589-3596
   Abstract »    Full Text »    PDF »
Autoimmune Hypophysitis of SJL Mice: Clinical Insights from a New Animal Model.
S.-C. Tzou, I. Lupi, M. Landek, A. Gutenberg, Y.-M. Tzou, H. Kimura, G. Pinna, N. R. Rose, and P. Caturegli (2008)
Endocrinology 149, 3461-3469
   Abstract »    Full Text »    PDF »
Control of Her-2 Tumor Immunity and Thyroid Autoimmunity by MHC and Regulatory T Cells.
J. B. Jacob, Y.-c. M. Kong, C. Meroueh, D. P. Snower, C. S. David, Y.-S. Ho, and W.-Z. Wei (2007)
Cancer Res. 67, 7020-7027
   Abstract »    Full Text »    PDF »
An MHC-linked locus modulates thymic differentiation of CD4+CD25+Foxp3+ regulatory T lymphocytes.
J. Tellier, J. P. M. van Meerwijk, and P. Romagnoli (2006)
Int. Immunol. 18, 1509-1519
   Abstract »    Full Text »    PDF »
Concurrent Induction of Antitumor Immunity and Autoimmune Thyroiditis in CD4+CD25+ Regulatory T Cell-Depleted Mice.
W.-Z. Wei, J. B. Jacob, J. F. Zielinski, J. C. Flynn, K. D. Shim, G. Alsharabi, A. A. Giraldo, and Y.-c. M. Kong (2005)
Cancer Res. 65, 8471-8478
   Abstract »    Full Text »    PDF »
Interleukin (IL)-12-Driven Primary Hypothyroidism: the Contrasting Roles of Two Th1 Cytokines (IL-12 and Interferon-{gamma}).
H. Kimura, S.-C. Tzou, R. Rocchi, M. Kimura, K. Suzuki, A. F. Parlow, N. R. Rose, and P. Caturegli (2005)
Endocrinology 146, 3642-3651
   Abstract »    Full Text »    PDF »
Iodine and IFN-{gamma} Synergistically Enhance Intercellular Adhesion Molecule 1 Expression on NOD.H2h4 Mouse Thyrocytes.
R. B. Sharma, J. D. Alegria, M. V. Talor, N. R. Rose, P. Caturegli, and C. L. Burek (2005)
J. Immunol. 174, 7740-7745
   Abstract »    Full Text »    PDF »
A Graves' Disease-Associated Kozak Sequence Single-Nucleotide Polymorphism Enhances the Efficiency of CD40 Gene Translation: A Case for Translational Pathophysiology.
E. M. Jacobson, E. Concepcion, T. Oashi, and Y. Tomer (2005)
Endocrinology 146, 2684-2691
   Abstract »    Full Text »    PDF »
Expression of Class II Major Histocompatibility Complex Molecules on Thyrocytes Does Not Cause Spontaneous Thyroiditis but Mildly Increases Its Severity after Immunization.
H. Kimura, M. Kimura, S.-C. Tzou, Y.-C. Chen, K. Suzuki, N. R. Rose, and P. Caturegli (2005)
Endocrinology 146, 1154-1162
   Abstract »    Full Text »    PDF »
H2A- and H2E-Derived CD4+CD25+ Regulatory T Cells: A Potential Role in Reciprocal Inhibition by Class II Genes in Autoimmune Thyroiditis.
G. P. Morris, Y. Yan, C. S. David, and Y.-c. M. Kong (2005)
J. Immunol. 174, 3111-3116
   Abstract »    Full Text »    PDF »
Common Allelic Variants of Exons 10, 12, and 33 of the Thyroglobulin Gene Are Not Associated with Autoimmune Thyroid Disease in the United Kingdom.
J. E. Collins, J. M. Heward, J. M. M. Howson, H. Foxall, J. Carr-Smith, J. A. Franklyn, and S. C. L. Gough (2004)
J. Clin. Endocrinol. Metab. 89, 6336-6339
   Abstract »    Full Text »    PDF »
Development of a Murine Model of Autoimmune Thyroiditis Induced with Homologous Mouse Thyroid Peroxidase.
H. P. Ng, J. Paul Banga, and A. W. C. Kung (2004)
Endocrinology 145, 809-816
   Abstract »    Full Text »    PDF »
Amino acid substitutions in the thyroglobulin gene are associated with susceptibility to human and murine autoimmune thyroid disease.
Y. Ban, D. A. Greenberg, E. Concepcion, L. Skrabanek, R. Villanueva, and Y. Tomer (2003)
PNAS 100, 15119-15124
   Abstract »    Full Text »    PDF »
Searching for the Autoimmune Thyroid Disease Susceptibility Genes: From Gene Mapping to Gene Function.
Y. Tomer and T. F. Davies (2003)
Endocr. Rev. 24, 694-717
   Abstract »    Full Text »    PDF »
Association of a Rare Thyroglobulin Gene Microsatellite Variant with Autoimmune Thyroid Disease.
J. E. Collins, J. M. Heward, J. Carr-Smith, J. Daykin, J. A. Franklyn, and S. C. L. Gough (2003)
J. Clin. Endocrinol. Metab. 88, 5039-5042
   Abstract »    Full Text »    PDF »
Thyroid-Specific Expression of IFN-{gamma} Limits Experimental Autoimmune Thyroiditis by Suppressing Lymphocyte Activation in Cervical Lymph Nodes.
J. G. Barin, M. Afanasyeva, M. V. Talor, N. R. Rose, C. L. Burek, and P. Caturegli (2003)
J. Immunol. 170, 5523-5529
   Abstract »    Full Text »    PDF »
The pathogenic role of anti-thyroglobulin antibody on pregnancy: evidence from an active immunization model in mice.
S. T. Matalon, M. Blank, Y. Levy, H. J.A. Carp, A. Arad, L. Burek, E. Grunebaum, Y. Sherer, A. Ornoy, S. Refetoff, et al. (2003)
Hum. Reprod. 18, 1094-1099
   Abstract »    Full Text »    PDF »
Delineation of Five Thyroglobulin T Cell Epitopes with Pathogenic Potential in Experimental Autoimmune Thyroiditis.
P. Verginis, M. M. Stanford, and G. Carayanniotis (2002)
J. Immunol. 169, 5332-5337
   Abstract »    Full Text »    PDF »
An Interval Tightly Linked to but Distinct From the H2 Complex Controls Both Overt Diabetes (Idd16) and Chronic Experimental Autoimmune Thyroiditis (Ceat1) in Nonobese Diabetic Mice.
O. Boulard, D. Damotte, N. Deruytter, G. Fluteau, C. Carnaud, and H.-J. Garchon (2002)
Diabetes 51, 2141-2147
   Abstract »    Full Text »    PDF »
A Novel Murine Model of Graves' Hyperthyroidism with Intramuscular Injection of Adenovirus Expressing the Thyrotropin Receptor.
Y. Nagayama, M. Kita-Furuyama, T. Ando, K. Nakao, H. Mizuguchi, T. Hayakawa, K. Eguchi, and M. Niwa (2002)
J. Immunol. 168, 2789-2794
   Abstract »    Full Text »    PDF »
A Unique Combination of Inflammatory Cytokines Enhances Apoptosis of Thyroid Follicular Cells and Transforms Nondestructive to Destructive Thyroiditis in Experimental Autoimmune Thyroiditis.
S. H. Wang, J. D. Bretz, E. Phelps, E. Mezosi, P. L. Arscott, S. Utsugi, and J. R. Baker Jr. (2002)
J. Immunol. 168, 2470-2474
   Abstract »    Full Text »    PDF »
The Discovery of Type 1 Diabetes.
E. A.M. Gale (2001)
Diabetes 50, 217-226
   Abstract »    Full Text »
Induction of Granulomatous Experimental Autoimmune Thyroiditis in IL-4 Gene-Disrupted Mice.
H. Tang, G. C. Sharp, K. E. Peterson, and H. Braley-Mullen (1998)
J. Immunol. 160, 155-162
   Abstract »    Full Text »    PDF »
Self-reactive B Cells Are Not Eliminated or Inactivated by Autoantigen Expressed on Thyroid Epithelial Cells.
S. Akkaraju, K. Canaan, and C. C. Goodnow (1997)
J. Exp. Med. 186, 2005-2012
   Abstract »    Full Text »    PDF »
Relation between the Major Histocompatibility (B) Locus and Autoimmune Thyroiditis in Obese Chickens.
L. D. Bacon, J. H. Kite Jr., and N. R. Rose (1974)
Science 186, 274-275
   Abstract »    PDF »
HL-A Antigens in Pemphigus.
S. I. Katz, M. V. Dahl, N. Penneys, R. J. Trapani, and N. Rogentine (1973)
Arch Dermatol 108, 53-55
   Abstract »    PDF »
Histocompatibility-Linked Immune Response Genes.
B. Benacerraf and H. O. McDevitt (1972)
Science 175, 273-279
   PDF »
Hypothyroidism in transgenic mice expressing IFN-gamma in the thyroid.
P. Caturegli, M. Hejazi, K. Suzuki, O. Dohan, N. Carrasco, L. D. Kohn, and N. R. Rose (2000)
PNAS 97, 1719-1724
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)