Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 26 November 1971:
Vol. 174. no. 4012, pp. 954 - 955
DOI: 10.1126/science.174.4012.954
Prev | Table of Contents | Next

Articles

Prenatal Cerebral Development: Effect of Restricted Diet, Reversal by Growth Hormone

Stephen Zamenof 1, Edith van Marthens 1, and Ludmila Grauel 1

1 Department of Medical Microbiology and Immunology, Department of Biological Chemistry, Brain Research Institute, and Mental Retardation Center, University of California School of Medicine, Los Angeles 90024

Caloric restriction of rats from day 10 to day 20 of pregnancy results in significant decreases in body weight, placental weight, cerebral weight, cerebral DNA, and cerebral protein of the offspring at birth. These decreases did not usually occur if mothers on the restricted diet were treated concomitantly with bovine growth hormone. If growth hormone did not cross the placenta, then, it is postulated, at least one effect of growth hormone was the mobilization of maternal nutrient reserves.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Prolongation of gestation by growth hormone: a confounding factor in the assessment of its prenatal action.
P. Croskerry and G. Smith (1975)
Science 189, 648-650
   Abstract »    PDF »
Fetal Bin Growth: Selective Action by Growth Hormone.
V. R. Sara, L. Lazarus, M. C. Stuart, and T. King (1974)
Science 186, 446-447
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)