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Science 26 November 1971:
Vol. 174. no. 4012, pp. 949 - 951
DOI: 10.1126/science.174.4012.949
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Articles

Strontium Induced Rickets: Metabolic Basis

J. L. Omdahl 1 and H. F. DeLuca 1

1 Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin, Madison 53706

Dietary strontium inhibits both the synthesis of 1,25-dihydroxycholecalciferol and intestinal calcium absorption in vitamin D3-repleted chicks. 1,25-Dihydroxycholecalciferol restores calcium absorption to normal, while 25-hydroxycholecalciferol is without effect in the strontium-fed chick. It is suggested that strontium induces rickets by blocking the biosynthesis of 1,25-dihydroxycholecalciferol, the metabolically active form of vitamin D in the intestine.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Aluminum, Iron, Lead, Cadmium, Copper, Zinc, Chromium, Magnesium, Strontium, and Calcium Content in Bone of End-Stage Renal Failure Patients.
P. C. D'Haese, M.-M. Couttenye, L. V. Lamberts, M. M. Elseviers, W. G. Goodman, I. Schrooten, W. E. Cabrera, and M. E. De Broe (1999)
Clin. Chem. 45, 1548-1556
   Abstract »    Full Text »    PDF »
Measurement of strontium in serum, urine, bone, and soft tissues by Zeeman atomic absorption spectrometry.
P. C. D'Haese, G. F. Van Landeghem, L. V. Lamberts, V. A. Bekaert, I. Schrooten, and M. E. De Broe (1997)
Clin. Chem. 43, 121-128
   Abstract »    Full Text »    PDF »
Review: Parenteral Nutrition-Related Bone Disease.
W. W.K. Koo (1992)
JPEN J Parenter Enteral Nutr 16, 386-394
   Abstract »    PDF »
Trace Element Abnormalities in Chronic Uremia.
W. R. SMYTHE, A. C. ALFREY, P. W. CRASWELL, C. A. CROUCH, L. S. IBELS, H. KUBO, L. L. NUNNELLEY, and H. RUDOLPH (1982)
Ann Intern Med 96, 302-310
   Abstract »    PDF »
Osteomalacia: Current Concepts.
B. FRAME and A. M. PARFITT (1978)
Ann Intern Med 89, 966-982
   Abstract »    PDF »
Vitamin D Endocrinology.
H. F. DeLUCA (1976)
Ann Intern Med 85, 367-377
   Abstract »    PDF »
Calcium Absorption and Calcium-Binding Protein Synthesis: Solanum malacoxylon Reverses Strontium Inhibition.
R. H. Wasserman (1974)
Science 183, 1092-1094
   Abstract »    PDF »
5,6-Trans-25-Hydroxycholecalciferol: Vitamin D Analog Effective on Intestine of Anephric Rats.
M. F. Holick, M. Garabedian, and H. F. DeLuca (1972)
Science 176, 1247-1248
   Abstract »    PDF »
1,25-Dihydroxycholecalciferol: Metabolite of Vitamin D3 Active on Bone in Anephric Rats.
M. F. Holick, M. Garabedian, and H. F. DeLuca (1972)
Science 176, 1146-1147
   Abstract »    PDF »


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