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Science 12 November 1971:
Vol. 174. no. 4010, pp. 717 - 719
DOI: 10.1126/science.174.4010.717
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Articles

Junctions between Cancer Cells in Culture: Ultrastructure and Permeability

Ross G. Johnson 1 and Judson D. Sheridan 1

1 Department of Zoology, University of Minnesota, Minneapolis 55455

Cell junctions between Novikoff hepatoma cells (N1S1-67) growing as small clumps or chains in suspension culture have been studied with ultrastructural, electrophysiological, and dye-injection techniques. Cells within clumps are commonly electrically coupled and can exchange dyes with a molecular weight of 332 to 500. Gap junctions and intermediate junctions are present, whereas true tight junctions and desmosomes are absent or very rare. This system should provide a useful model for studying the properties of "communicating" junctions.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Quantification of gap junction selectivity.
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Am J Physiol Cell Physiol 289, C1535-C1546
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Islets of Langerhans: dye coupling among immunocytochemically distinct cell types.
R. Michaels and J. Sheridan (1981)
Science 214, 801-803
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Size limit of molecules permeating the junctional membrane channels.
I Simpson, B Rose, and W. Loewenstein (1977)
Science 195, 294-296
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Permeable Junctions.
W. R. Loewenstein (1976)
Cold Spring Harb Symp Quant Biol 40, 49-63
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Cell Junctions in Development, with Particular Reference to the Neural Tube.
J.-P. Revel and S. S. Brown (1976)
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Mobility and the Restriction of Mobility of Plasma Membrane Lectin-Binding Components.
G. L. Nicolson and R. Yanagimachi (1974)
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Membrane-Associated Particles: Increase at Sites of Pinocytosis Demonstrated by Freeze-Etching.
L. Orci and A. Perrelet (1973)
Science 181, 868-869
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Science. ISSN 0036-8075 (print), 1095-9203 (online)