Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 12 November 1971:
Vol. 174. no. 4010, pp. 704 - 707
DOI: 10.1126/science.174.4010.704
Prev | Table of Contents | Next

Articles

Herpesvirus Type 2 Isolated from Cervical Tumor Cells Grown in Tissue Culture

Laure Aurelian 1, John D. Strandberg 2, Luis V. Melendez 3, and Lorna A. Johnson 4

1 Departments of Laboratory Animal Medicine and Microbiology, Johns Hopkins School of Medicine, Baltimore, Maryland
2 Departments of Laboratory Animal Medicine and Pathology, Johns Hopkins School of Medicine
3 New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts
4 Department of Pathology, Harvard Medical School, Boston, Massachusetts

A herpesvirus has been isolated from spontaneously degenerating cultures of cervical tumor cells grown in vitro. The virus was identified as a type 2 herpesvirus on the basis of biologic properties, including plaque morphology and microtubule formation in infected HEp-2 cells, and of immunologic specificity as determined by neutralization. Herpesvirus antigens and virus particles were not seen in duplicate cultures of viable cervical tumor cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Demonstration of the Oncogenic Potential of Herpes Simplex Viruses and Human Cytomegalovirus.
F. Rapp and J.-L. H. Li (1974)
Cold Spring Harb Symp Quant Biol 39, 747-763
   Abstract »    PDF »
Antibody to HSV-2 Induced Tumor Specific Antigens in Serums from Patients with Cervical Carcinoma.
L. Aurelian, B. Schumann, R. L. Marcus, and H. J. Davis (1973)
Science 181, 161-164
   Abstract »    PDF »
Immunologic Manipulation of Metastases due to Herpesvirus Transformed Cells.
R. Duff, E. Doller, and F. Rapp (1973)
Science 180, 79-81
   Abstract »    PDF »
Herpesvirus Type 2 in the Male Genitourinary Tract.
Y. M. Centifanto, D. M. Drylie, S. L. Deardourff, and H. E. Kaufman (1972)
Science 178, 318-319
   Abstract »    PDF »
Recent Advances in Oncology.
D. L. MORTON, C. M. HASKELL, Y. H. PILCH, F. C. SPARKS, and W. D. WINTERS (1972)
Ann Intern Med 77, 431-454
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)