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Science 12 November 1971:
Vol. 174. no. 4010, pp. 704 - 707
DOI: 10.1126/science.174.4010.704
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Articles

Herpesvirus Type 2 Isolated from Cervical Tumor Cells Grown in Tissue Culture

Laure Aurelian 1, John D. Strandberg 2, Luis V. Melendez 3, and Lorna A. Johnson 4

1 Departments of Laboratory Animal Medicine and Microbiology, Johns Hopkins School of Medicine, Baltimore, Maryland
2 Departments of Laboratory Animal Medicine and Pathology, Johns Hopkins School of Medicine
3 New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts
4 Department of Pathology, Harvard Medical School, Boston, Massachusetts

A herpesvirus has been isolated from spontaneously degenerating cultures of cervical tumor cells grown in vitro. The virus was identified as a type 2 herpesvirus on the basis of biologic properties, including plaque morphology and microtubule formation in infected HEp-2 cells, and of immunologic specificity as determined by neutralization. Herpesvirus antigens and virus particles were not seen in duplicate cultures of viable cervical tumor cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Antibody to HSV-2 Induced Tumor Specific Antigens in Serums from Patients with Cervical Carcinoma.
L. Aurelian, B. Schumann, R. L. Marcus, and H. J. Davis (1973)
Science 181, 161-164
   Abstract »    PDF »
Immunologic Manipulation of Metastases due to Herpesvirus Transformed Cells.
R. Duff, E. Doller, and F. Rapp (1973)
Science 180, 79-81
   Abstract »    PDF »
Herpesvirus Type 2 in the Male Genitourinary Tract.
Y. M. Centifanto, D. M. Drylie, S. L. Deardourff, and H. E. Kaufman (1972)
Science 178, 318-319
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)