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Science 12 November 1971:
Vol. 174. no. 4010, pp. 702 - 704
DOI: 10.1126/science.174.4010.702
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Articles

Polymorphism of Human Constitutive Heterochromatin

Ann P. Craig-Holmes 1 and Margery W. Shaw 1

1 Department of Biology, Graduate School of Biomedical Sciences, and M. D. Anderson Hospital and Tumor Institute, University of Texas at Houston, Houston 77025

Genetic polymorphism has been demonstrated in man for many characteristics including blood groups, serum proteins, tissue enzymes, and hemoglobins. A class of chromosomal polymorphism involving constitutive heterochromatin has now been found. Through the use of a special technique that permits visualization of heterochromatin, seven heterochromatin variants have been found among four individuals. These results suggest a very high frequency of variability of heterochromatin in the population.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Islands of euchromatin-like sequence and expressed polymorphic sequences within the short arm of human chromosome 21.
R. Lyle, P. Prandini, K. Osoegawa, B. ten Hallers, S. Humphray, B. Zhu, E. Eyras, R. Castelo, C. P. Bird, S. Gagos, et al. (2007)
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High genetic instability of heterochromatin after transposition of the LINE-like I factor in Drosophila melanogaster.
P. Dimitri, B. Arca, L. Berghella, and E. Mei (1997)
PNAS 94, 8052-8057
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DNA Content and DNA-Based Centromeric Index of the 24 Human Chromosomes.
M. L. Mendelsohn, B. H. Mayall, E. Bogart, D. H. Moore II, and B. H. Perry (1973)
Science 179, 1126-1129
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