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Science 12 November 1971:
Vol. 174. no. 4010, pp. 696 - 698
DOI: 10.1126/science.174.4010.696
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Articles

Acridine Orange Potentiation of Actinomycin D Uptake and Activity

Eugene F. Roth Jr. 1 and Joseph Kochen 1

1 Division of Hematology, Departments of Medicine and Pediatrics, Montefiore Hospital and Medical Center, and Albert Einstein College of Medicine, Bronx, New York 10467

Acridine orange enhances the uptake of [3H]actinomycin D in disrupted and intact human lymphocytes, as measured by liquid scintillation and autoradiography. Proflavine, quinacrine, chloroquine, and ethidium bromide are not effective. In mice, acridine orange increases the capacity of actinomycin to reduce spleen weight. Type II acridine binding to DNA may be a prerequisite for actinomycin enhancement.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)