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Science 5 November 1971:
Vol. 174. no. 4009, pp. 591 - 593
DOI: 10.1126/science.174.4009.591
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Articles

Immunotherapy of Cancer: Immunospecific Rejection of Tumors in Recipients of Neuraminidase-Treated Tumor Cells Plus BCG

Richard L. Simmons 1 and Angelyn Rios 1

1 Department of Surgery, University of Minnesota, Minneapolis 55455

Firmly established methylcholanthrene fibrosarcomas in syngeneic mice will totally disappear if the hosts are treated with living tumor cells that have been exposed to Vibrio cholerae neuraminidase in vitro. The effect is magnified by the simultanieous injection of a nonspecific immunostimulant, BCG. The rejection of the methylcholanthrene tumor is immunospecific and can be induced only with tumor cells, treated with Vibrio cholerae neuraminidase, identical in type with the growing tumor.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Immunotherapy and Human Tumor Immunology.
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Ann Intern Med 84, 454-465
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Immunologic Mechanisms in the Prevention and Therapy of Cancer.
T. A. Fleisher and J. H. Kersey (1974)
Arch Pediatr Adolesc Med 128, 739-742
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Immunologic Modification: A Basic Survival Mechanism.
B. B. Jacobs and D. E. Uphoff (1974)
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Science. ISSN 0036-8075 (print), 1095-9203 (online)