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Science 5 November 1971:
Vol. 174. no. 4009, pp. 589 - 591
DOI: 10.1126/science.174.4009.589
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Articles

Marihuana: Standardized Smoke Administration and Dose Effect Curves on Heart Rate in Humans

Pierre F. Renault 1, Charles R. Schuster 1, Richard Heinrich 1, and Daniel X. Freeman 1

1 Department of Psychiatry, 950 East 59 Street, University of Chicago, Chicago, Illinois 60637

A spirometer was used to deliver marihuana and placebo smoke to human subjects. This procedure produced linear dose-effect curves on heart rate and replicable dose effects in individual subjects. No differences were observed between experienced and inexperienced smokers in responsiveness to heart rate increases produced by marihuana.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)