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Science 22 October 1971:
Vol. 174. no. 4007, pp. 421 - 422
DOI: 10.1126/science.174.4007.421
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Articles

Disposition of Morphine in Man

Sydney Spector 1 and Elliott S. Vesell 2

1 Department of Physiological Chemistry, Roche Institute of Molecular Biology, Nutley, New Jersey 07110
2 Department of Pharmacology, Milton S. Hershey Medical Center, Pennsylvania State University, College of Medicine, Hershey 17033

The disposition of morphine was investigated by means of radioimmunoassay after a single intravenous dose (10 milligrams per 70 kilograms) was administered to 10 adult normal male subjects who had not received other drugs for 2 weeks preceding the study. A multiphasic decline in serum concentrations of morphine occurred. Detectable blood concentrations of morphine, or of a metabolite, or of both persisted for 48 hours after a single intravenous dose.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Guide to Drug Usage in Adult Patients With Impaired Renal Function: A Supplement.
W. M. Bennett, I. Singer, and C. H. Coggins (1973)
JAMA 223, 991-997
   Abstract »    PDF »
Evidence for Active Immunity to Morphine in Mice.
B. Berkowitz and S. Spector (1972)
Science 178, 1290-1292
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)