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Science 8 October 1971:
Vol. 174. no. 4005, pp. 142 - 144
DOI: 10.1126/science.174.4005.142
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Articles

Cyclic Adenosine 3',5'-Monophosphate during Glucose Repression in the Rat Liver

Oscar Sudilovsky 1, Angel Pestana 1, Paul H. Hinderaker 1, and Henry C. Pitot 1

1 Departments of Oncology and Pathology, McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706

Intragastric administration of glucose inhibits the induction of serine dehydratase and tyrosine aminotransferase by glucagon in rat liver, but has no effect on the increase in hepatic adenosine 3',5'-monophosphate resulting from administration of glucagon. Thus, glucose repression in mammalian liver, unlike catabolite repression in microorganisms, appears to operate independently of the amounts of cyclic nucleotide in the cells.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)