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Science 8 October 1971:
Vol. 174. no. 4005, pp. 139 - 141
DOI: 10.1126/science.174.4005.139
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Articles

L-Asparaginase Induced Immunosuppression: Inhibition of Bone Marrow Derived Antibody Precursor Cells

Herman Friedman 1

1 Department of Microbiology, Albert Einstein Medical Center, Philadelphia, Pennsylvania 19141

The cooperation between bone marrow and thymus cells in restoring the hemolytic antibody response to sheep erythrocytes in immunosuppressed recipients was markedly inhibited when donor mice were treated with L-asparaginase, a known inhibitor of lymphocyte function. The marrow cell population was shown to be a major target for the immunosuppressive activity of asparaginase, since thymus cells from enzyme-treated animals interacted with marrow cells from normal animals to generate immunocompetent cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Alanyl-Glutamine Consumption Modifies the Suppressive Effect of L-Asparaginase on Lymphocyte Populations in Mice.
P. Bunpo, B. Murray, J. Cundiff, E. Brizius, C. J. Aldrich, and T. G. Anthony (2008)
J. Nutr. 138, 338-343
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Science. ISSN 0036-8075 (print), 1095-9203 (online)