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Science 1 October 1971:
Vol. 174. no. 4004, pp. 74 - 76
DOI: 10.1126/science.174.4004.74
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Articles

Morphine Tolerance and Dependence Induced by Intraventricular Injecfion

E. Eidelberg 1 and C. A. Barstow 1

1 Division of Neurobiology, Barrow Neurological Institute of St. Joseph's Hospital and Medical Center, Phoenix, Arizona 85013

Injection of small quantities of morphine into the cerebral ventricular system of awake, relatively unrestrained, monkeys depressed or abolished operant food-reinforced lever pressing. After repeated injections progressively higher doses of morphine were needed to depress responding. Also, dependence could be demonstrated in these animals by precipitating specific abstinence signs with an antagonist.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Absence of cross-tolerance to heroin in morphine-tolerant mice.
D. Lange, S. Roerig, J. Fujimoto, and R. Wang (1980)
Science 208, 72-74
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Science. ISSN 0036-8075 (print), 1095-9203 (online)