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Science 1 October 1971:
Vol. 174. no. 4004, pp. 62 - 64
DOI: 10.1126/science.174.4004.62
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Articles

Persistent Increase in Brain Serotonin Turnover after Chronic Administration of LSD in the Rat

Josè-Luis DìAz 1 and Matti O. Huttunen 1

1 Psychiatric Research Laboratories, Massachusetts General Hospital, Boston 02114

Lysergic acid diethylamide at doses of 20 micrograms per kilogram per day was administered orally to rats for I month. Eighteen hours after the final dose a 25 to 30 percent increase in the synthesis and turnover of serotonin was noted, as well as a moderate but significant increase in the concentration of tryptophan (18 percent) and serotonin (13 percent) in the brain.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
REVIEW {blacksquare} : Long-lasting Effects of Recreational Drugs of Abuse on the Central Nervous System.
U. D. McCann, K. A. Lowe, and G. A. Ricaurte (1997)
Neuroscientist 3, 399-411
   Abstract »    PDF »
Acute Psychosis Induced by Psychotomimetic Drug Abuse: II. Neurochemical Findings.
M. B. Bowers Jr. (1972)
Arch Gen Psychiatry 27, 440-442
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)