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Science 24 September 1971:
Vol. 173. no. 4003, pp. 1245 - 1246
DOI: 10.1126/science.173.4003.1245
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Articles

Linkage of Genes Controlling the Rate of Synthesis and Structure of Aminolevulinate Dehydratase

D. L. Coleman 1

1 Jackson Laboratory, Bar Harbor, Maine 04609

The rate of synthesis of dgr-aminolevulinate dehydratase in mice is controlled by alleles at the levulinate (Lv) locus. Two structural mutations modifying the sensitivity of dgr-aminolevulinate dehydratase to heat have been identified. Genetic analyses established that the structural locus for dgr-aminolevulinate dehydratase was either physically close to or identical with the locus that controls its rate of synthesis.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)