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Science 24 September 1971:
Vol. 173. no. 4003, pp. 1242 - 1243
DOI: 10.1126/science.173.4003.1242
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Articles

Thyroxine: Conversion to Triiodothyronine by Isolated Perfused Rat Heart

Joseph L. Rabinowitz 1 and Eileen S. Hercker 1

1 Veterans Administration Hospital and University of Pennsylvania School of Dental Medicine, Philadelphia 19104

Thyroxine labeled with carbon-14 and iodine-125 was perfused through surviving rat hearts. Only when unlabeled triiodothyronine was added as a carrier could the newly formed doubly labeled triiodothyronine be isolated. The fact that this triiodothyronine was labeled with the correct ratio of carbon-14 to iodine-125 indicated that it originated from thyroxine. Approximately 5 percent of the initial carbon-14 radioactivity was found in the recovered triiodothyronine.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Conversion of Thyroxine to Triiodothyronine by Cultured Human Cells.
K. Sterling, M. A. Brenner, and V. F. Saldanha (1973)
Science 179, 1000-1001
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