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Science 10 September 1971:
Vol. 173. no. 4001, pp. 1022 - 1024
DOI: 10.1126/science.173.4001.1022
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Articles

[3H]Lysergic Acid Diethylamide:Cellular Autoradiographic Localization in Rat Brain

I. M. Diab 1, D. X. Freedman 1, and L. J. Roth 1

1 Departments of Pharmacology and Psychiatry,University of Chicago, Chicago, Illinois 60637

Intravenous administration of [3H]lysergic acid diethylamide(LSD) to rats resulted in accumulation of the drug in the brain within 15 minutes. Autoradiographic methods were used to differentiate free and bound [3H]LSD in brain tissue.Free [3H]LSD was generally distributed in the pituitary and pineal glands, cerebellum, hippocampus,and choroid plexus.Bound [3H]LSD was localized in neurons of the cortex, caudate nucleus, midbrain, and medulla,as well as in choroid plexus epithelium.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Lysergic acid diethylamide: effect on histone acetylation in rabbit brain.
I. Brown and C. Liew (1975)
Science 188, 1122-1123
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