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Science 27 August 1971:
Vol. 173. no. 3999, pp. 833 - 835
DOI: 10.1126/science.173.3999.833
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Articles

L-Dopa: Disaggregation of Brain Polysomes and Elevation of Brain Tryptophan

Bette F. Weiss 1, Hamish N. Munro 1, and Richard J. Wurtman 1

1 Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge 02139

One hour after administration of L-dopa (50 to 300 milligrams per kilogram), there is a marked disaggregation of brain polysomes in immature rats. Adult animals show a similar response, but require larger doses of the amino acid (500 milligrams per kilogram). Single doses of L-dopa significantly elevate amounts of tryptophan in the brain; hence their effect on polysomes does not result from the unavailability of this amino acid.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Dopamine: Mediator of Brain Polysome Disaggregation after L-Dopa.
B. F. Weiss, H. N. Munro, L. A. Ordonez, and R. J. Wurtman (1972)
Science 177, 613-616
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