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Science 27 August 1971:
Vol. 173. no. 3999, pp. 829 - 832
DOI: 10.1126/science.173.3999.829
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Articles

Human Fetal Cerebellar Cortex: Organization and Maturation of Cells in vitro

Lowell W. Lapham 1 and William R. Markesbery 1

1 Departments of Pathology and Neutrology, Universiy of Rochester Medical Center, Rochester, New York 14642

Human fetal cerebellar cortex was maintained up to 5 months in vitro. Important features included early migration of granule neurons followed by maturation of Purkinje and granule neurons. Unique areas of organization developed in which a rim of leptomeningeal cells surrounded an explant and its outgrowth zone; these areas subsequently grew as well-defined units.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
In Memoriam: Lowell Winship Lapham (1922-2006).
R. A. Brumback (2007)
J Child Neurol 22, 1314-1320
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The Lysosome: A Role in Disease.
M. A. VERITY, R. ANDIMAN, T. L. MUNSAT, R. E. SMITH, and C. M. SZEGO (1973)
Ann Intern Med 78, 725-738
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)