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Science 20 August 1971:
Vol. 173. no. 3998, pp. 745 - 747
DOI: 10.1126/science.173.3998.745
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Articles

Cyclic 3',5'-Nucleotide Phosphodiesterase: Cytochemical Localization in Cerebral Cortex

Noel T. Florendo 1, Russell J. Barrnett 1, and Paul Greengard 1

1 Departments of Anatomy and Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510

The distribution of cyclic 3',5'-nucleotide phosphodiesterase activity in rat cerebral cortex was determined by cytochemical methods. The detectable phosphodiesterase activity was localized in postsynaptic (dendritic) nerve endings, most of it immediately adjacent to the synaptic membrane. Most of the postsynaptic nerve endings showed phosphodiesterase activity.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cyclic Nucleotides, Protein Phosphorylation and Synaptic Function.
K. G. Beam and P. Greengard (1976)
Cold Spring Harb Symp Quant Biol 40, 157-168
   Abstract »    PDF »
Adenosine 3', 5'-Monophosphate in Cerebrospinal Fluid: Effect of Drugs and Neurologic Disease.
H. Cramer, L. K. Y. Ng, and T. N. Chase (1973)
Arch Neurol 29, 197-199
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)