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Science 20 August 1971:
Vol. 173. no. 3998, pp. 743 - 745
DOI: 10.1126/science.173.3998.743
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Articles

Histamine Augments Leukocyte Adenosine 3',5'-Monophosphate and Blocks Antigenic Histamine Release

Henry R. Bourne 1, Kenneth L. Melmon 1, and Lawrence M. Lichtenstein 2

1 Departments of Medicine and Pharmacology, University of California School of Medicine, San Francisco 94122
2 Department of Medicine, Johns Hopkins University School of Medicine at the Good Samaritan Hospital, Baltimore, Maryland 21212

Extracellular histamine stimulates accumulation of adenosine 3',5'-monophosphate in human leukocytes and prevents antigenic release of histamine from cells of allergic donors. Both effects occur at histamine concentrations that can be achieved by antigenic release of the amine in vitro.


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Ann Intern Med 85, 39-43
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Modulation of Inflammation and Immunity by Cyclic AMP.
H. R. Bourne, Y. Weinstein, K. L. Melmon, L. M. Lichtenstein, C. S. Henney, and G. M. Shearer (1974)
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Receptors for Histamine Can Be Detected on the Surface of Selected Leukocytes.
K. L. Melmon, H. R. Bourne, J. Weinstein, and M. Sela (1972)
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