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Science 20 August 1971:
Vol. 173. no. 3998, pp. 738 - 740
DOI: 10.1126/science.173.3998.738
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Articles

Origin of 5-Hydroxyindoleacetic Acid in the Spinal Fluid

M. Bulat 1 and B. Zcaronivkovicacute 1

1 Institute Ruder Boscaronkovicacute, Bijeniccaronka 54, 41000 Zagreb, Yugoslavia

5-Hydroxyindoleacetic acid applied intracisternally in cats does not appear in spinal fluid. Changes of 5-hydroxyindoleacetic acid concentration in the spinal cord are clearly reflected in the perfusate of the spinal subarachnoid space. Thus, 5-hydroxyindoleacetic acid in the spinal fluid originates from the spinal cord and reflects metabolic changes of 5-hydroxytryptamine in the spinal tissue, but not those in the brain.


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