Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 13 August 1971:
Vol. 173. no. 3997, pp. 642 - 643
DOI: 10.1126/science.173.3997.642
Prev | Table of Contents | Next

Articles

DDT Administered to Neonatal Rats Induces Persistent Estrus Syndrome

W. L. Heinrichs 1, R. J. Gellert 1, J. L. Bakke 2, and N. L. Lawrence 2

1 Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle 98195
2 Pacific Northwest Research Foundation, 1102 Columbia Street, Seattle, Washington 98104

The o,p'-isomer of the insecticide DDT when injected into neonatal female rats significantly advanced puberty, induced persistent vaginal estrus after a period of normal estrous cycles, and caused the ovaries to develop follicular cysts and a reduced number of corpora lutea. The uterotropic response to administered estradiol was reduced, and the female pattern of mating behavior was slightly disturbed. Residues of DDT in ovarian, brain, and adipose tissues of the adult animals were the same in both treated and control groups.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mechanisms of Interaction of Endocrine-Disrupting Chemicals with Glutamate-Evoked Secretion of Gonadotropin-Releasing Hormone.
G. Rasier, A.-S. Parent, A. Gerard, R. Denooz, M.-C. Lebrethon, C. Charlier, and J.-P. Bourguignon (2008)
Toxicol. Sci. 102, 33-41
   Abstract »    Full Text »    PDF »
Early Maturation of Gonadotropin-Releasing Hormone Secretion and Sexual Precocity after Exposure of Infant Female Rats to Estradiol or Dichlorodiphenyltrichloroethane.
G. Rasier, A.-S. Parent, A. Gerard, M.-C. Lebrethon, and J.-P. Bourguignon (2007)
Biol Reprod 77, 734-742
   Abstract »    Full Text »    PDF »
Pesticide Exposure and Timing of Menopause: The Agricultural Health Study.
S. L. Farr, J. Cai, D. A. Savitz, D. P. Sandler, J. A. Hoppin, and G. S. Cooper (2006)
Am. J. Epidemiol. 163, 731-742
   Abstract »    Full Text »    PDF »
Age at Menarche in Relation to Maternal Use of Tobacco, Alcohol, Coffee, and Tea during Pregnancy.
G. C. Windham, C. Bottomley, C. Birner, and L. Fenster (2004)
Am. J. Epidemiol. 159, 862-871
   Abstract »    Full Text »    PDF »
Sex-Dependent Regulation of Hepatic Cytochrome P-450 by DDT.
A. Sierra-Santoyo, M. Hernandez, A. Albores, and M. E. Cebrian (2000)
Toxicol. Sci. 54, 81-87
   Abstract »    Full Text »    PDF »
Tamoxifen and Prevention of Breast Cancer.
J. D. Sherman (1998)
Toxicology and Industrial Health 14, 485-499
   PDF »
Estrogenic activity of the insecticide kepone on the chicken oviduct.
R. Palmiter and E. Mulvihill (1978)
Science 201, 356-358
   Abstract »    PDF »
Specificity of neonatal, androgen-induced imprinting of hepatic steroid metabolism in rats.
J Gustafsson and A Stenberg (1976)
Science 191, 203-204
   Abstract »    PDF »
Metabolic Interactions Among Environmental Chemicals and Drugs: Environmental chemicals that alter microsomal activity may influence the safety and efficacy of drugs.
A. H. Conney and J. J. Burns (1972)
Science 178, 576-586
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)