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Science 13 August 1971:
Vol. 173. no. 3997, pp. 629 - 633
DOI: 10.1126/science.173.3997.629
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Articles

Variation and Homology in the Mu and Gamma Heavy Chains of Human Immunoglobulins

Akira Shimizu 1, Claudine Paul 1, Heinz Köhler 1, Tomotaka Shinoda 1, and Frank W. Putnam 1

1 Department of Zoology, Indiana University, Bloomington 47401

Sequence analysis of an 1gM immunoglobulin shows that the variable regions of hunman µ and ggr1 heavy chainis may have twice as much homology as their constant regions and that evolutionary divergence of µ and ggr1 heavy chain genes occurred not long after the separation of heavy and light chain genes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Immunoglobulin Genes: Arranged in Tandem or in Parallel?.
O. Smithies (1974)
Cold Spring Harb Symp Quant Biol 38, 725-737
   Abstract »    PDF »
Complete Amino Acid Sequence of the Mu Heavy Chain of a Human IgM Immunoglobulin.
F. W. Putnam, G. Florent, C. Paul, T. Shinoda, and A. Shimizu (1973)
Science 182, 287-291
   Abstract »    PDF »
Initiation of Protein Synthesis at an Unusual Position in an Immunoglobulin Gene?.
O. Smithies and M. D. Poulik (1972)
Science 175, 187-189
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)