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Science 6 August 1971:
Vol. 173. no. 3996, pp. 550 - 553
DOI: 10.1126/science.173.3996.550
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Articles

Bilateral Symmetry and Interneuronal Organization in the Buccal Ganglia of Aplysia

Daniel Gardner 1

1 Department of Physiology and Biophysics, New York University School of Medicine, and Department of Neurobiology and Behavior, Public Health Research Institute of the City of New York, New York 10016

Principles of functional organization of the bilaterally symmetric buccal ganglia of Aplysia were studied in 20 identified cells used as a reference population. Four of the identified cells (two in each ganglion) are multiaction interneurons, each of which innervates six identified ipsilateral follower cells, mediating cholinergic excitation to one cell and cholinergic inhibition to five others. Bilateral coordination is effected by common inputs to all four interneurons. Ipsilateral pairs of interneurons are electrotonically coupled and produce identical synaptic actions on their common follower population. This apparent redundancy of interneuronal action leads to feed-forward summation, eliciting amplified synaptic output from each interneuron pair.


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Identification and Characterization of Catecholaminergic Neuron B65, Which Initiates and Modifies Patterned Activity in the Buccal Ganglia of Aplysia.
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Different Roles of Neurons B63 and B34 That Are Active During the Protraction Phase of Buccal Motor Programs in Aplysia californica.
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Serotonin and the Small Cardioactive Peptides Differentially Modulate Two Motor Neurons That Innervate the Same Muscle Fibers in Aplysia.
L. E. Fox and P. E. Lloyd (1997)
J. Neurosci. 17, 6064-6074
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The Secretion of Classical and Peptide Cotransmitters from a Single Presynaptic Neuron Involves a Synaptobrevin-Like Molecule.
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A Pair of Identified Interneurons in Aplysia that Are Involved in Multiple Behaviors Are Necessary and Sufficient for the Arterial-Shortening Component of a Local Withdrawal Reflex.
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Neuropeptides: mediators of behavior in Aplysia.
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Aspartate: distinct receptors on Aplysia neurons.
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D. Gardner and E. R. Kandel (1972)
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