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Science 6 August 1971:
Vol. 173. no. 3996, pp. 548 - 550
DOI: 10.1126/science.173.3996.548
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Articles

Contraction of Granulation Tissue in vitro: Similarity to Smooth Muscle

G. Majno 1, G. Gabbiani 1, B. J. Hirschel 1, G. B. Ryan 1, and P. R. Statkov 1

1 Department of Pathology, University of Geneva, 1205 Geneva, Switzerland

Strips of granulation tissue from three different experimental models contract in vitro when treated with substances that induce contraction of smooth muscle. Because the fibroblasts in such tissues have some ultrastructural features typical of smooth muscle, our findings indicate that fibroblasts are able to modulate toward a cell type that is morphologically and functionally close to smooth muscle.


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