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Science 6 August 1971:
Vol. 173. no. 3996, pp. 542 - 544
DOI: 10.1126/science.173.3996.542
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Articles

Human Lymphocyte Antigen Reactivity Modified by Neuraminidase

Emily A. Grothaus 1, M. Wayne Flye 2, Emund Yunis 3, and D. B. Amos 4

1 Division of Immunology, Duke Medical Center, Durham, North Carolina 27706
2 Department of Surgery and Division of Immunology, Duke Medical Center
3 Blood Bank and Department of Immunology, University of Minnesota, Minneapolis 55455
4 Division of Immunology, Duke Medical Center

Human lymphocytes treated with neuraminidase (from Vibrio cholera) are more susceptible to lysis with antiserums directed against HL-A antigens in the cytotoxicity test than are the corresponding cells incubated in buffer. Enzymetreated cells are also lysed by antibodies other than those directed against HL-A, but control cells are not. The extra sensitivity to antibody disappears after 2 to 6 days in tissue culture.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)