Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 23 July 1971:
Vol. 173. no. 3994, pp. 338 - 340
DOI: 10.1126/science.173.3994.338
Prev | Table of Contents | Next

Articles

Acetylcholine Binding to Torpedo Electroplax: Relationship to Acetylcholine Receptors

Mohyee E. Eldefrawi 1, Alan G. Britten 1, and Amira T. Eldefrawi 1

1 Section of Neurobiology and Behavior, Cornell University, Ithaca, New York 14850

Binding of [3H]acetylcholine to a particulate fraction of Torpedo electroplax was measured by equilibrium dialysis. Two high-affinity sites present on phospholipoproteins bound acetylcholine reversibly, and binding was blocked by nicotinic drugs. Characteristics of this binding suggest that these phospholipoproteins may be acetylcholine receptors.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Characterization of Torpedo californica Acetylcholine Receptor: Its Subunit Composition and Ligand-binding Properties.
M. A. Raftery, R. L. Vandlen, K. L. Reed, and T. Lee (1976)
Cold Spring Harb Symp Quant Biol 40, 193-202
   Abstract »    PDF »
Some Structural Properties of the Cholinergic Receptor Protein in Its Membrane Environment Relevant to Its Function as a Pharmacological Receptor.
J.-P. Changeux, L. Benedetti, J.-P. Bourgeois, A. Brisson, J. Cartaud, P. Devaux, H. Grunhagen, M. Moreau, J.-L. Popot, A. Sobel, et al. (1976)
Cold Spring Harb Symp Quant Biol 40, 211-230
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)